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RETRA hydrobromide

CAS No. 1035875-01-4

RETRA hydrobromide( RETRA )

Catalog No. M10178 CAS No. 1035875-01-4

RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RETRA hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
  • Description
    RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RETRA
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1035875-01-4
  • Formula Weight
    350.245
  • Molecular Formula
    C11N11NO3S2.HBr
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=CC=C(C(CSC2=NCCS2)=O)C=C1O.[H]Br
  • Chemical Name
    2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrobromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7. 2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51. 3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.
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